Effect of angiotensins on calcitonin gene-related peptide (CGRP)-containing nerve-mediated vasodilation in the rat mesenteric vascular bed.
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چکیده
منابع مشابه
Calcitonin Gene-Related Peptide (CGRP)
Calcitonin gene-related peptide (CGRP) is a 37 amino acid vasoactive neuropeptide that is widely distributed in central and peripheral nervous systems in mammals. CGRP was discovered in 1982 by molecular cloning of calcitonin (CT) gene. CGRP-specific mRNA appears to predominate in the hypothalamus while CT mRNA predominates in the thyroid. CGRP has an amphiphilic α-helical secondary structure i...
متن کاملProton acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the rat mesenteric artery.
Nicotine stimulates presynaptic nicotinic acetylcholine receptors in perivascular adrenergic nerves and releases unknown transmitter(s) that activate transient receptor potential vanilloid-1 (TRPV1) located on calcitonin gene-related peptide (CGRP)-containing (CGRPergic) nerves, resulting in vasodilation. The present study investigated a potential transmitter transmitting between perivascular a...
متن کاملThe mechanism of calcitonin gene-related peptide-containing nerve innervation.
Calcitonin gene-related peptide (CGRP) is a major neurotransmitter and CGRP-containing primary sensory neurons play an important role in nociception and potent vasodilation. CGRP-containing nerves in mesenteric arteries are decreased in pathological animal models (hypertension, diabetes, and atherosclerosis). In apolipoprotein E–knockout mice, which have atherosclerosis and peripheral sen...
متن کاملStructure-activity study of chicken calcitonin gene-related peptide (CGRP) on vasorelaxation in rat mesenteric resistance vessels.
Structure-activity relationship of the chicken calcitonin gene-related peptide (cCGRP) was investigated and compared with human-alpha-CGRP (hCGRP) and rat CGRP (rCGRP) in the perfused mesenteric vascular beds of rats. In precontracted mesenteric vascular beds, cCGRP, hCGRP and rCGRP produced a concentration-dependent vasodilation. The vasodilator activities of cCGRP and rCGRP were equipotent an...
متن کاملThe Effect of Anabolic Androgenic Steroids on Calcitonin Gene-related Peptide (cgrp) Levels in the Rat Brain
Objective: The aim of the present study was to determine whether anabolic androgenic steroids (AAS) have an effect on the levels of calcitonin gene-related peptide (CGRP) in the rat brain, using nandrolone decanoate as a prototype steroid. Method: Male Sprague-Dawley rats received daily intramuscular injections of nandrolone decanoate (15 mg/kg) for 14 days. The effect of AAS on CGRP immunoreac...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1991
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)39136-x